|
|
H+ + L-Dopa <=> dopamine + CO2
|
4.1.1.22
histidine decarboxylase
4.1.1.25
tyrosine decarboxylase
4.1.1.28
aromatic-L-amino-acid decarboxylase
4.1.1.53
phenylalanine decarboxylase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BR287
KEGG:
R02080
MetaCyc:
RXN66-221
SABIO-RK:
2090
|
|
|
|
L-Dopa + O2 <=> H+ + 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde
|
1.13.11
1.13.11.29
stizolobate synthase
|
–
–
|
MK
|
|
BRENDA:
BR37128
KEGG:
R02075;
R08836
MetaCyc:
RXN-8460
|
|
|
|
L-Dopa + O2 <=> H+ + 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde
|
1.13.11.30
stizolobinate synthase
|
–
|
MK
|
|
BRENDA:
BR37131
KEGG:
R02076
MetaCyc:
STIZOLOBINATE-SYNTHASE-RXN
|
|
|
|
L-Dopa + 2-oxoglutarate <=> 3,4-Dihydroxyphenylpyruvate + L-glutamate
|
2.6.1.27
tryptophan transaminase
2.6.1.49
dihydroxyphenylalanine transaminase
2.6.1.5
tyrosine transaminase
|
–
–
–
|
MK
|
|
BRENDA:
BR47392
KEGG:
R02077
MetaCyc:
2.6.1.49-RXN
SABIO-RK:
2087
|
|
|
|
L-Dopa + NADH + H+ <=> 3,4-Dihydroxyphenylpropionate + NAD+ + NH3
|
4.3.1.22
3,4-dihydroxyphenylalanine reductive deaminase
|
–
|
K
|
|
BRENDA:
BR48857
KEGG:
R08846
MetaCyc:
4.3.1.22-RXN
|
|
|
|
L-Dopa + O2 <=> 3,4-Dihydroxyphenylpyruvate + NH3
|
1.13.12.15
3,4-dihydroxyphenylalanine oxidative deaminase
|
–
|
K
|
|
BRENDA:
BR48962
KEGG:
R08920
MetaCyc:
RXN-9773
|
|
|
|
L-tyrosine + O2 <=> L-Dopa
|
1.10.3.1
catechol oxidase
1.14.18.1
tyrosinase
|
–
–
|
MK
|
|
BRENDA:
BR50166
KEGG:
R00031;
R00731
MetaCyc:
RXN-5861
SABIO-RK:
1094;
622
|
|
|
|
L-Dopa + O2 <=> dopaquinone + H2O
|
1.10.3
1.10.3.1
catechol oxidase
1.14.18.1
tyrosinase
|
–
–
–
|
MK
|
|
BRENDA:
BR50167;
BS289494
KEGG:
R00045
MetaCyc:
RXN-13061
SABIO-RK:
635;
7344
|
|
|
|
L-Dopa + O2 + H2O <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2
|
4.1.1.107
3,4-dihydroxyphenylacetaldehyde synthase
4.1.1.108
4-hydroxyphenylacetaldehyde synthase
|
–
–
|
K
|
|
BRENDA:
BR52267
KEGG:
R11916
MetaCyc:
RXN-19275
|
|
|
|
L-tyrosine + H2O2 <=> L-Dopa + H2O
|
1.11.2.6
L-tyrosine peroxygenase
1.14.18.1
tyrosinase
|
–
–
|
MK
|
|
BRENDA:
BR53064
KEGG:
R12611
MetaCyc:
RXN-21208
|
|
|
|
S-adenosyl-L-methionine + L-Dopa <=> methyl_3-hydroxy-L-tyrosinate + S-adenosyl-L-homocysteine + H+
|
2.1.1.6
catechol O-methyltransferase
|
–
|
M
|
|
BRENDA:
BS409647
MetaCyc:
RXN-10870
|
|
|
|
L-tyrosine + O2 + FADH2 <=> L-Dopa + H2O + FAD + H+
|
1.14.14
1.14.14.9
4-hydroxyphenylacetate 3-monooxygenase
|
–
–
|
M
|
|
BRENDA:
BS428763
MetaCyc:
RXN-14990
|
|
|
|
L-Dopa <=> caffeic_acid + NH3
|
4.3.1.23
tyrosine ammonia-lyase
4.3.1.25
phenylalanine/tyrosine ammonia-lyase
|
–
–
|
M
|
|
BRENDA:
BS445601
MetaCyc:
RXN-14987
|
|
|
|
L-tyrosine + tetrahydropteridine + O2 <=> L-Dopa + a_4a-hydroxy-5,6,7,8-tetrahydropteridine
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
B
|
|
BRENDA:
BR40405
KEGG:
R12541
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + dihydrobiopterin + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
K
|
|
BRENDA:
BS370244
KEGG:
R01815
SABIO-RK:
1901
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydrobiopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
K
|
|
BRENDA:
BS377086
KEGG:
R07212
SABIO-RK:
7156
|
|
|
|
L-tyrosine + L-Dopa + O2 <=> L-Dopa + dopaquinone + H2O
|
1.10.3.1
catechol oxidase
1.14.18.1
tyrosinase
|
–
–
|
K
|
|
BRENDA:
BS386549
KEGG:
R02078
|
|
|
|
2-Carboxy-2,3-dihydro-5,6-dihydroxyindole + dopaquinone <=> L-Dopachrome + L-Dopa
|
not assigned
|
–
|
MK
|
|
KEGG:
R03672
MetaCyc:
RXN-11369
|
|
|
|
L-Dopa + Betalamate <=> H+ + Dopaxanthin + H2O
|
not assigned
|
–
|
MK
|
|
KEGG:
R08827
MetaCyc:
RXN-8491
|
|
|
|
L-Dopa + phenylpyruvate <=> 3,4-Dihydroxyphenylpyruvate + L-phenylalanine
|
2.6.1.49
dihydroxyphenylalanine transaminase
|
–
|
|
|
BRENDA:
BS353597
SABIO-RK:
12100
|
|
|
|
L-Dopa + O2 <=> L-Dopachrome + H2O
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS397525
SABIO-RK:
6926
|
|
|
|
L-Dopa <=> salsolinol
|
not assigned
|
–
|
|
|
KEGG:
R08443
|
|
|
|
2-S-cysteinyldopa + dopaquinone <=> 2-S-cysteinyldopaquinone + L-Dopa
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18894
|
|
|
|
Cysteinyldopa + dopaquinone <=> 5-S-cysteinyldopaquinone + L-Dopa
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18895
|
|
|
|
L-tyrosine + tetrahydropteridine + O2 <=> L-Dopa + 4a-hydroxytetrahydropteridine
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
M
|
|
MetaCyc:
TYROSINE-3-MONOOXYGENASE-RXN
|
|
|
|
D-tyrosine + L-Dopa + O2 <=> D-Dopa + dopaquinone + H2O
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS388479
|
|
|
|
dimethylallyl_diphosphate + L-Dopa <=> diphosphate + 3-hydroxy-4-dimethylallyloxy-L-phenylalanine
|
2.5.1.122
4-O-dimethylallyl-L-tyrosine synthase
|
–
|
|
|
BRENDA:
BS437404
|
|
|
|
L-Dopa + H2O + O2 <=> 3,4-Dihydroxyphenylpyruvate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
1.4.3.3
D-amino-acid oxidase
|
–
–
|
|
|
BRENDA:
BS383802
|
|
|
|
3-fluoro-L-Tyr + H2O2 <=> 3-fluoro-5-hydroxyl-L-tyrosine + L-Dopa + F-
|
1.11.2.6
L-tyrosine peroxygenase
|
–
|
|
|
BRENDA:
BS455002
|
|
|
|
3-chloro-L-tyrosine + H2O2 <=> 3-chloro-5-hydroxyl-L-tyrosine + L-Dopa + Cl-
|
1.11.2.6
L-tyrosine peroxygenase
|
–
|
|
|
BRENDA:
BS454995
|
|
|
|
L-tyrosine + 6-methyl-tetrahydrobiopterin + O2 <=> L-Dopa + 6-methyl-4a-hydroxytetrahydrobiopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS397671
|
|
|
|
L-tyrosine + 6-Methyl-5,6,7,8-tetrahydropterin + O2 <=> L-Dopa + 6-methyl-4a-hydroxytetrahydrobiopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS451339
|
|
|
|
L-tyrosine + O2 + reduced_acceptor <=> L-Dopa + H2O + A
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS353306
|
|
|
|
D-tyrosine + O2 + reduced_acceptor <=> L-Dopa + H2O + A
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS396943
|
|
|
|
L-tyrosine + ascorbate + O2 <=> L-Dopa + dehydroascorbate + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
1.14.17.B1
|
–
–
|
|
|
BRENDA:
BS288203
|
|
|
|
3-iodo-L-tyrosine + H2O2 <=> 3-iodo-5-hydroxyl-L-tyrosine + L-Dopa + I-
|
1.11.2.6
L-tyrosine peroxygenase
|
–
|
|
|
BRENDA:
BS455013
|
|
|
|
L-Dopa + H2O + 2 cytochrome_b <=> 3,4-Dihydroxyphenylpyruvate + NH3 + 2 reduced_cytochrome_b
|
1.4.99.B3
|
–
|
|
|
BRENDA:
BS439653
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydro-L-biopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS405668
|
|
|
|
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS288194
|
|
|
|
L-tyrosine + tetrahydropteridine + O2 <=> L-Dopa + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS398928
|
|
|
|
L-phenylalanine + tetrahydropteridine + O2 <=> L-Dopa + dihydropteridine + H2O
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
|
|
BRENDA:
BS288205
|
|
|
|
L-tyrosine + H2O <=> L-Dopa
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS409729
|
|
|
|
L-Dopa + H2O <=> catechol + NH3 + pyruvate
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18616
|
|
|
|
DL-tyrosine + H2O2 <=> L-Dopa + H2O
|
1.11.2.6
L-tyrosine peroxygenase
|
–
|
|
|
BRENDA:
BS455590
|
|
|
|
catechol + pyruvate <=> L-Dopa + H2O
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS376456
|
|
|
|
(R)-tyrosine-betaxanthin + L-Dopa + O2 <=> (R)-dopaxanthin + dopaquinone + H2O
|
1.10.3.1
catechol oxidase
1.14.18.1
tyrosinase
|
–
–
|
|
|
BRENDA:
BS386893
|
|
|
|
L-Dopa + NADPH <=> 3,4-Dihydroxyphenylpropionate + NADP+ + NH3
|
4.3.1.22
3,4-dihydroxyphenylalanine reductive deaminase
|
–
|
|
|
BRENDA:
BS387308
|
|
|
|
L-Dopa + O2 <=> dopachrome + H2O
|
1.10.3.1
catechol oxidase
1.14.18.1
tyrosinase
|
–
–
|
|
|
BRENDA:
BS377034
|
|
|
|
L-Dopa <=> 3-amino-3-(3,4-dihydroxyphenyl)propanoate
|
5.4.3.6
tyrosine 2,3-aminomutase
|
–
|
|
|
BRENDA:
BS368775
|
|
|
|
L-serine + catechol <=> L-Dopa + H2O
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18638
|
|
|
|
ATP + L-Dopa + tRNAMet <=> AMP + L-3,4-dihydroxyphenylalanine-tRNATyr + diphosphate
|
6.1.1.1
tyrosine---tRNA ligase
|
–
|
|
|
BRENDA:
BS368847
|
|
|
|
ATP + L-Dopa + tRNAMet <=> AMP + diphosphate + 3,4-dihydroxy-L-phenylalanyl-tRNAPhe
|
6.1.1.20
phenylalanine---tRNA ligase
|
–
|
|
|
BRENDA:
BS428213
|
|
|
|
L-Dopa + oxaloacetate <=> 3,4-Dihydroxyphenylpyruvate + L-aspartate
|
2.6.1.49
dihydroxyphenylalanine transaminase
|
–
|
|
|
BRENDA:
BS353596
|
|
|
|
L-Dopa + O2 <=> L-dopaquinone + H2O2
|
1.14.18.1
tyrosinase
|
–
|
|
|
SABIO-RK:
7341
|
|